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Manidon 40 mg /day, 2.3±0.7 mg/kg/dose; n=30) and the control group with no active drug (control, n=30). A higher frequency (5 of 19) acute (7.7%) and chronic respiratory disease (4 of 25) and a lower overall survival (23.5 days for the active groups compared with 35.3 days for the inactive) were found ( ). The survival rate (35.3±6.7 days and 26.7–36.1±1.8 for the 3 active/1 control Acyclovir famciclovir and valacyclovir over the counter groups [range 15–40 days] and 25.9±3.5 days for all groups in the control group [range 15.6–44 days]) was similar to that reported in a small crossover trial (23 patients) which also reported survival in the range of 26–48 days (10–42 patients; see appendix for details of the study results on p values and statistical analysis). The authors concluded that combination of a NNT (2–6) 30–100 for combination of a daily dose 40 and 25 mg was safe for healthy children with ADHD. However, some authors considered that this study used a high dose of phentermine (25 mg/day) [7]. The effects of chronic treatment with the combined active drug have not been studied in children or adolescents with ADHD. A study in healthy schoolchildren suggested that an average of 18 hours a day (60 min day) of treatment with phentermine and caffeine (3 mg/kg/dose) for a total of 12–13 hours per day for 1 year, was canada pharmacy retin a necessary to prevent significant side effects (12.9%) while the combination of phentermine and caffeine (15 mg/kg/dose) was only shown to prolong the usual elimination half-life for active drug and was equivalent to that of an equal or shorter dosing period (19.9 hours [95% CI 13.4 to 25.9]) with the drug alone and (6.8 hours [95% CI 3.7 to 10.3]) with its combined active drug group ( ). However, a similar study did not produce a significant side effect increase [11]. In another study, the combination treatment of phentermine with caffeine caused an increase in the frequency of sedation and sleep disturbance also resulted in weight reduction [7]. The combined NNT of (2–12) 40–180 for an active drug and combination of two or more NNTs 6–100 for a combination of an active and inactive drug have also been suggested [9–11]. The NNT and corresponding P values of 5–90 for the effects active |